Enteric bacteria and HLA-B27 associated cell surface modification in patients with seronegative spondarthritis

Cytotoxic studies indicate cross-reactivity between some enteric organisms and cells obtained from the majority of patients with ankylosing spondylitis. Preliminary studies suggest that the factor responsible for cross-reactivity may be generated by a bacterial plasmid. However, the mechanism mediat...

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Veröffentlicht in:	British journal of rheumatology 1983-11, Vol.22 (4 Suppl 2), p.75
Hauptverfasser:	Edmonds, J, Geczy, A F, Sullivan, J S, Prendergast, J K, Upfold, L I, Bashir, H V
Format:	Artikel
Sprache:	eng
Schlagworte:	Cross Reactions Cytotoxicity Tests, Immunologic Enterobacteriaceae Infections - complications Enterobacteriaceae Infections - immunology HLA Antigens - immunology HLA-B27 Antigen Humans Lymphocytes - immunology Spondylitis, Ankylosing - diagnosis Spondylitis, Ankylosing - etiology Spondylitis, Ankylosing - immunology
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Beschreibung
Zusammenfassung:	Cytotoxic studies indicate cross-reactivity between some enteric organisms and cells obtained from the majority of patients with ankylosing spondylitis. Preliminary studies suggest that the factor responsible for cross-reactivity may be generated by a bacterial plasmid. However, the mechanism mediating the interaction between the HLA-B27 positive cell and the bacterial antigen is at present unknown.
ISSN:	0263-7103