Mixed lymphocyte reactivity in spleen cells from F-9 tumor-bearing mice: II. Functional cross-reactivity between F-9 cells and testicular cells
Previous serological analysis has revealed cross-reactive antigens on F-9 cells and mouse germ cells. Therefore, we investigated whether suppressor activity in spleen cells from F-9 tumor-bearing mice can be restimulated in vitro by adding F-9 cells or testicular cells to mixed lymphocyte cultures....
Gespeichert in:
Veröffentlicht in: | Cellular immunology 1981-08, Vol.62 (2), p.341-349 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Previous serological analysis has revealed cross-reactive antigens on F-9 cells and mouse germ cells. Therefore, we investigated whether suppressor activity in spleen cells from F-9 tumor-bearing mice can be restimulated
in vitro by adding F-9 cells or testicular cells to mixed lymphocyte cultures. We found equal potentiation of suppressor T-cell activity with F-9 cells and with syngeneic testicular cells; as shown by sensitivity to anti-Lyt 2.2 plus complement treatment. Suppressor activity of spleen cells from other tumor systems tested was not enhanced. The data suggest that the same or cross-reactive antigens on F-9 teratocarcinoma cells and testicular cells may have similar regulatory functions. |
---|---|
ISSN: | 0008-8749 1090-2163 |
DOI: | 10.1016/0008-8749(81)90335-X |