Calcium antagonists in hypertensive disease: experimental evidence for a new therapeutic concept

In animal experiments calcium antagonist drugs decrease peripheral vascular resistance, improve renal sodium excretion and thus, diminishing the volume load, reduce cardiac hypertrophy. In experimental malignant hypertension these drugs preserve tissue integrity by inhibiting the deleterious calcium...

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Veröffentlicht in:	Postgraduate medical journal 1983, Vol.59 Suppl 2, p.78
Hauptverfasser:	Kazda, S, Garthoff, B, Luckhaus, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries - metabolism Blood Pressure - drug effects Calcium - metabolism Calcium Channel Blockers - therapeutic use Hypertension - complications Hypertension - drug therapy Hypertension - pathology Hypertension, Malignant - drug therapy Male Rats Vascular Diseases - drug therapy Vascular Diseases - etiology
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Zusammenfassung:	In animal experiments calcium antagonist drugs decrease peripheral vascular resistance, improve renal sodium excretion and thus, diminishing the volume load, reduce cardiac hypertrophy. In experimental malignant hypertension these drugs preserve tissue integrity by inhibiting the deleterious calcium overload of vessels.
ISSN:	0032-5473