CLINICAL EVALUATION OF PIVMECILLINAM IN THE MAINTENANCE THERAPY OF CHRONIC URINARY TRACT INFECTION

In order to evaluate the efficacy and safety ofpivmecillinam (melysin tablet, PMPC), PMPC was administered to 78 chronic UTI cases in the field of obstetrics and gynecology (posthysterectomy infection, chronic cystitis, chronic pyelonephritis and etc.). In principle, daily 400mg of PMPC was administ...

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Veröffentlicht in:Japanese journal of antibiotics 1981/09/25, Vol.34(9), pp.1278-1287
Hauptverfasser: TAMAYA, TERUHIKO, TSURUSAKI, TOSHIHIDE, KUSANISHI, HIROSHI, OKADA, HIROJI, YAMAMOTO, HIROSHI, AHARA, MICHIMASA, MURAKAMI, AKIRA, TAKANO, NOBORU, OBATA, TADASHI, SHIMURA, TATSUOKI, IWASAKI, TAKEKI, NAKATA, YOSHINORI, FUTAOKA, SUMINORI, OHSHIMA, KAZUYA, FURUTA, NORIO, MURAKAMI, TOSHIKI, OHTANI, ITSUO, SUGIHARA, YOUICHI, YUASA, MITSUO, MIZUNOYA, FUJIO, OTA, SATOSHI, FUJITA, HIROO, UEHA, ITARU, KATOH, KEIICHI
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Zusammenfassung:In order to evaluate the efficacy and safety ofpivmecillinam (melysin tablet, PMPC), PMPC was administered to 78 chronic UTI cases in the field of obstetrics and gynecology (posthysterectomy infection, chronic cystitis, chronic pyelonephritis and etc.). In principle, daily 400mg of PMPC was administered for 2 weeks. (1) Overall clinical efficacy judged by doctor was evaluated in 78 cases and the result was; excellent in 17, good in 37, fair in 10, poor in 13 and unknown in 1 case with the effectiveness rate ofm 69.2%. (2) Overall clinical efficacy judged by criteria for clinical evaluation in complicated UTI recommended by UTI study member was evaluated in 54 cases and the result was; excellent in 15, good in 20 and poor in 19 cases with the overall efficacy rate of 64.8%, the result of which was similar to that of doctor's judgement. (3) Efficacy on pyuria was evaluated in 72 cases and it was cleared in 27, decreased in 25, unchanged in 20 and unknown in 6 cases. Efficacy on bacteriuria was evaluated in 72 cases and it was eliminated in 44, decreased in 9, replaced in 8, unchanged in 8 and unknown in 9 cases. (4) Side effect, considered by doctors to be caused by PMPC administration, was noticed in 3 out of 78 cases (3.8%), all of which was mild gastrointestinal disturbance and the administration of PMPC, was continued. Abnormal change of laboratory finding considered by doctors to be caused by PMPC administration was noticed in 1 out of 78 cases, which was slight elevation of GOT and GPT values. It is therefore considered that PMPC appear to be useful drug for the maintenance therapy of chronic UTI in the field of obstetrics and gynecology.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.34.1278