Immunologic phenomena in habitual abortion

12 women with recurrent abortions are investigated for various immunological parameters. Couples studied shared several HLA antigens, those women do not develop HLA' antibodies and cellular cytotoxicity against their husband. Their serum has an abnormal glycoprotein, migrating in the alpha glob...

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Veröffentlicht in:Comptes rendus des seances de la Societe de biologie et de ses filiales 1982, Vol.176 (5), p.656
Hauptverfasser: Bousquet, J, Fizet, D, Grobon, F, Dubecq, J P
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Sprache:fre
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Zusammenfassung:12 women with recurrent abortions are investigated for various immunological parameters. Couples studied shared several HLA antigens, those women do not develop HLA' antibodies and cellular cytotoxicity against their husband. Their serum has an abnormal glycoprotein, migrating in the alpha globulin zone, precipitating with anti beta globulin serum. The women studied with recurrent abortions never possessed the Blocking Factor present in the serum of pregnant women, able to inhibit a cellular cytotoxicity reaction in vitro. It is proposed a reliable and simple test which could inform on the outcome of abortions.
ISSN:0037-9026