Induction of teratocarcinoma cell differentiation: Effect of the inhibitors of DNA synthesis

Induction of teratocarcinoma cell (F9) differentiation was studied by using inhibitors of DNA synthesis and several agents known to be differentiation inducers. Inhibition of DNA synthesis induced changes in cell surface marker F9 and stimulated the production of plasminogen activator (PA) in a mann...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental cell research 1983-01, Vol.146 (2), p.439-444
Hauptverfasser:	Nishimune, Yoshitake, Kume, Akinori, Ogiso, Yuko, Matsushiro, Aizo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - analysis Biological and medical sciences Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Culture Media Demecolcine - pharmacology DNA - biosynthesis Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Plasminogen Activators - biosynthesis Protein Biosynthesis RNA - biosynthesis Teratoma - metabolism Teratoma - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Induction of teratocarcinoma cell (F9) differentiation was studied by using inhibitors of DNA synthesis and several agents known to be differentiation inducers. Inhibition of DNA synthesis induced changes in cell surface marker F9 and stimulated the production of plasminogen activator (PA) in a manner that is dependent upon de novo synthesis of RNA and protein. The results thus indicate close association between inhibition of DNA synthesis and induction of cell differentiation. This approach will be useful in investigating the mechanism of teratocarcinoma cell differentiation.
ISSN:	0014-4827 1090-2422
DOI:	10.1016/0014-4827(83)90147-7