Effect of cholinomimetics on the release and uptake of L-[3H] glutamic acid in rat neostriatum

The effects of cholinomimetics on the release and uptake of L-glutamic acid have been studied by means of local superfusion of rat neostriatum (in vivo) and using striatum slices (in vitro). Cholinomimetics regulate the release of L-glutamic acid through both muscarinic (m-) and nicotinic (n-) choline receptors according to the mechanism of negative feedback. Cholinomimetics regulate release through presynaptic receptors. The effect of n-cholinomimetics is mediated by neostriatum interneurons.