Aflatoxin B1: Binding to DNA in vitro and Alteration of RNA Metabolism in vivo

Aflatoxin B$_{1}$ binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extreme toxicity and carcinogenicity of aflatoxin B$_{1}$ may be...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1966-03, Vol.151 (3717), p.1539-1541
Hauptverfasser:	Sporn, Michael B., Dingman, C. Wesley, Phelps, Harriette Longacre, Wogan, Gerald N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption spectra Aflatoxins Aflatoxins - pharmacology Animals Aspergillus Carcinogens - pharmacology Cellular metabolism Dialysis DNA In Vitro Techniques Liver Liver - cytology Liver - enzymology Liver - metabolism Nuclear RNA Nucleosides - metabolism Potassium phosphates Rats RNA RNA - biosynthesis Spectrophotometry Toxins Toxins, Biological - pharmacology Transaminases - biosynthesis Tritium Tryptophan Oxygenase - biosynthesis
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Zusammenfassung:	Aflatoxin B$_{1}$ binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extreme toxicity and carcinogenicity of aflatoxin B$_{1}$ may be direct results of the affinity of this agent for DNA.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.151.3717.1539