Combined Effect of Cobalt and Testosterone on Erythropoiesis

Combined Effect of Cobalt and Testosterone on Erythropoiesis

Summary It has been demonstrated that a combination of cobalt and testosterone serves to potentiate erythropoiesis in the polycythemic mouse, and acts synergistically to increase erythropoietin levels in the plasma of the normal mouse. When these 2 substances are used together, the erythropoietic re...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1965-11, Vol.120 (2), p.443-446
Hauptverfasser: Janda, Wayne E., Fried, Walter, Gurney, Clifford W.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cobalt - pharmacology
Drug Synergism
Erythropoiesis - drug effects
Mice
Polycythemia
Testosterone - pharmacology
Transfusion Reaction
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Zusammenfassung:Summary It has been demonstrated that a combination of cobalt and testosterone serves to potentiate erythropoiesis in the polycythemic mouse, and acts synergistically to increase erythropoietin levels in the plasma of the normal mouse. When these 2 substances are used together, the erythropoietic response in plethoric animals and the amount of erythropoietin elaborated in normal animals are substantially greater than the sum of the responses produced by each agent separately.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-120-30558