Inhibition by 5-Fluorouracil of the Early Stages of Chemical Carcinogenesis in Mouse Skin

Summary 5-FU was found to inhibit the early stages of DMBA-induced epidermal carcinogenesis in the mouse. The dose which must be employed to obtain this effect is of the same order of magnitude as that required for bringing about regression of established tumors of the mouse skin.

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Bibliographische Detailangaben
Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1969-09, Vol.131 (4), p.1135-1137
Hauptverfasser:	Olson, P. R., Wattenberg, L. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benz(a)Anthracenes Cell Transformation, Neoplastic - drug effects Depression, Chemical Female Fluorouracil - pharmacology Mice Neoplasms, Experimental - chemically induced Skin - drug effects Skin Neoplasms - chemically induced
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Beschreibung
Zusammenfassung:	Summary 5-FU was found to inhibit the early stages of DMBA-induced epidermal carcinogenesis in the mouse. The dose which must be employed to obtain this effect is of the same order of magnitude as that required for bringing about regression of established tumors of the mouse skin.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-131-34054