Passive Permeation of Organic Compounds through Biological Tissue: a Non-Steady-State Theory

Passive Permeation of Organic Compounds through Biological Tissue: a Non-Steady-State Theory

A theoretical analysis of the penetration of drug molecules to their sites of action in terms of their lipophilic character is presented. This analysis justifies the parabolic equations which have been used empirically to describe the relationship between effectiveness of drug and its lipophilic cha...

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Veröffentlicht in:Molecular pharmacology 1969-07, Vol.5 (4), p.333
Hauptverfasser: Penniston, J T, Beckett, L, Bentley, D L, Hansch, C
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological Transport
Cell Membrane Permeability - drug effects
Eye - drug effects
Insecta
Insecticides - metabolism
Kinetics
Lipid Metabolism
Mathematics
Models, Biological
Rabbits
Receptors, Drug - drug effects
Skin - drug effects
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Zusammenfassung:A theoretical analysis of the penetration of drug molecules to their sites of action in terms of their lipophilic character is presented. This analysis justifies the parabolic equations which have been used empirically to describe the relationship between effectiveness of drug and its lipophilic character.
ISSN:0026-895X
1521-0111