Induction of Intestinal and Urinary Bladder Cancer in Rats by Feeding Bracken Fern (Pteris aquilina)

Simultaneous intestinal and urinary bladder tumors were induced in rats by feeding them bracken fern (Pteris aquilina). Adenomatous polyps and adenocarcinomas developed predominantly in the ileum. These neoplasms were homogeneous and were sharply demarcated from adjacent normal mucosa. Urinary bladd...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1969-07, Vol.43 (1), p.275-281
Hauptverfasser:	Pamukcu, A. M., Price, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemically induced Animals Carcinoma - chemically induced Carcinoma, Papillary - chemically induced Carcinoma, Transitional Cell - chemically induced Intestinal Neoplasms - chemically induced Intestine, Small Neoplasms, Experimental - chemically induced Papilloma - chemically induced Plants Polyps - chemically induced Rats Urinary Bladder Neoplasms - chemically induced Urinary Bladder Neoplasms - pathology
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Beschreibung
Zusammenfassung:	Simultaneous intestinal and urinary bladder tumors were induced in rats by feeding them bracken fern (Pteris aquilina). Adenomatous polyps and adenocarcinomas developed predominantly in the ileum. These neoplasms were homogeneous and were sharply demarcated from adjacent normal mucosa. Urinary bladder tumors consisted of papillomas and carcinomas, and a high degree of malignancy followed the bracken feeding.
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/43.1.275