Inhibitory Effect of L-Ascorbate on Tumor Formation in Urinary Bladders Implanted with 3-Hydroxyanthranilic Acid

Summary A 2 × 2 factorial experiment was done to test the interaction of ascorbic acid and 3-hydroxyanthranilic acid on the development of malignant and total tumors in the urinary bladders of mice. An analysis of the data showed that the probability of survival was the same in all groups of mice an...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1969-06, Vol.131 (2), p.522-524
Hauptverfasser:	Pipkin, G. E., Schlegel, J. U., Nishimura, R., Shultz, G. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic Acid - pharmacology Ascorbic Acid - urine Female Methods Mice Neoplasms, Experimental - chemically induced ortho-Aminobenzoates - antagonists & inhibitors ortho-Aminobenzoates - pharmacology Urinary Bladder Neoplasms - chemically induced
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Beschreibung
Zusammenfassung:	Summary A 2 × 2 factorial experiment was done to test the interaction of ascorbic acid and 3-hydroxyanthranilic acid on the development of malignant and total tumors in the urinary bladders of mice. An analysis of the data showed that the probability of survival was the same in all groups of mice and that ascorbic acid inhibited the anticipated carcinogenic effect of 3-hydroxyanthranilic acid.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-131-33916