Imidazoles V: 5(or 4)-(3-alkyl-3-methyl-1-triazeno)imidazole-4(or 5)-Carboxamides

Several 5(or 4)-(3-alkyl-3-methyl-1-triazeno)imidazole-4(or 5)-carboxamides (III-X) were prepared from 5-diazoimidazole-4-carboxamide and the appropriate N-alkyl methylamine. Most of these derivatives significantly increased the life span of leukemic (L1210) mice. Inhibition of the growth of sarcoma 180, adenocarcinoma 755, and Walker carcinosarcoma 256 was observed, but inhibition of solid tumors was generally accompanied by large, adverse, host-weight changes. Qualitative observations of the sensitivity to light of aqueous alcoholic solutions of the dimethyltriazeno (NSC-45388) and the butylmethyltriazeno derivatives indicate a pronounced variation in stability with the kind of light exposure.