Anti-inflammatory Properties of Alkyl-pseudothioureas with Antibacterial and Antifungal Activity

Summary From a series of alkyl-pseudothioureas studied, 10-undecen-1-yl-thiopseudourea iodide (AHR-1911) was selected as antifungal-antibacterial agent for topical use. The preparation possesses in vitro and in the local infection of mice an anti-infective activity on the order of the antibiotics. T...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1971-04, Vol.136 (4), p.1328-1331
Hauptverfasser:	Ercoli, N., Arbona, Juan, Tabernero, Esther
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - antagonists & inhibitors Administration, Topical Animals Anti-Bacterial Agents Anti-Infective Agents - pharmacology Anti-Inflammatory Agents - pharmacology Antifungal Agents - pharmacology Arthritis - chemically induced Arthritis - drug therapy Arthrodermataceae - drug effects Bacteria - drug effects Blood Pressure - drug effects Burns - drug therapy Candida - drug effects Candidiasis - drug therapy Carrageenan Depression, Chemical Dextrans Gastrointestinal Motility - drug effects Guinea Pigs Hindlimb Kaolin Mice Rabbits Rats Staphylococcal Infections - drug therapy Thiourea
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Zusammenfassung:	Summary From a series of alkyl-pseudothioureas studied, 10-undecen-1-yl-thiopseudourea iodide (AHR-1911) was selected as antifungal-antibacterial agent for topical use. The preparation possesses in vitro and in the local infection of mice an anti-infective activity on the order of the antibiotics. This activity is associated with a considerable antiphlogistic action demonstrated in experimental arthritis of various types and in burns induced on rat skin.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-136-35485