IMMUNOSUPPRESSIVE AND ANTITUMOR ACTIVITIES OF N-METHYL-BIS(3-MESYLOXYPROPYL)AMINE HYDROCHLORIDE AND BIS(3-MESYLOXYPROPYL)AMINE HYDROCHLORIDE

N-Methyl-bis(3-mesyloxypropyl)amine hydrochloride and cyclophosphamide were shown to be effective against L-1210 and Walker carcinosarcoma-256, and were immuno-suppressive to mice immunized with sheep erythrocytes. Bis(3-mesyloxypropyl)amine hydrochloride was also inhibitory to L-1210, C-1498, and W...

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Veröffentlicht in:	GANN Japanese Journal of Cancer Research 1970/08/31, Vol.61(4), pp.397-401
Hauptverfasser:	OOTSU, Koichiro, MATSUMOTO, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - pharmacology Animals Antineoplastic Agents - pharmacology Hemagglutination Tests Immunosuppressive Agents - pharmacology Injections, Intraperitoneal Injections, Intravenous Leukocyte Count Mice Neoplasms, Experimental Propylamines - administration & dosage Propylamines - pharmacology Rats Sulfonic Acids - administration & dosage Sulfonic Acids - pharmacology
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Zusammenfassung:	N-Methyl-bis(3-mesyloxypropyl)amine hydrochloride and cyclophosphamide were shown to be effective against L-1210 and Walker carcinosarcoma-256, and were immuno-suppressive to mice immunized with sheep erythrocytes. Bis(3-mesyloxypropyl)amine hydrochloride was also inhibitory to L-1210, C-1498, and Walker carcinosarcoma-256, but had less immunosuppressive activity. Nitromin and Myleran were almost ineffective.
ISSN:	0016-450X
DOI:	10.20772/cancersci1959.61.4_397