Jumping Activity Induced by Sodium 5-(l,3-Dymethylbutyl)-5-Ethyl Barbiturate II. The Effects of Age Difference

Summary In small doses (12.5–20.0 mg/kg ip), DMBEB produced greater jumping activity in 1-month- than in 9-month-old mice, both in the rates of jumping as well as in number of jumping mice. There were no appreciable differences between young and old mice with large doses (22.5–25.0 mg/kg). The brain levels of DMBEB were similar in young and old mice. Jumping was markedly reduced in old and young mice by the beta-adrenergic blocking agent, propranolol, and the ganglionic blocking agent, chlorisondamine. Both propranolol and chlorisondamine prevented convulsions and death from a large dose of DMBEB (22.5 mg/kg). The authors thank Mr. Morton Raff and Mr. William Blackwelder, Biometrics Research Branch of the National Heart and Lung Institute, for the statistical analyses of the data reported in this paper.