Selective Destruction of Adrenal Cortex by Pulse Doses of Derivatives of 12-methylbenz(a)anthracene
Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1969-03, Vol.62 (3), p.704-707 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 62 |
| creator | Huggins, Charles Morii, Sotokichi Pataki, John |
| description | Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism. |
| doi_str_mv | 10.1073/pnas.62.3.704 |
| format | Article |
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The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.62.3.704</identifier><identifier>PMID: 5256999</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Adrenal cortex ; Adrenal Glands - drug effects ; Animals ; Aromatic hydrocarbons ; Benz(a)Anthracenes - administration & dosage ; Benz(a)Anthracenes - pharmacology ; Biological Sciences: Medical Sciences ; Emulsions ; Hemorrhage ; Hemorrhage - chemically induced ; Hydrocarbons ; Injections, Intravenous ; Lipids ; Medical sciences ; Metabolism ; Molecules ; Necrosis ; Rats</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1969-03, Vol.62 (3), p.704-707</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-4b20fd87368a1ac47f8b84dc9720bafa12f242a39b4ef7684212c18a5f306b243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/62/3.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/59162$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/59162$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5256999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huggins, Charles</creatorcontrib><creatorcontrib>Morii, Sotokichi</creatorcontrib><creatorcontrib>Pataki, John</creatorcontrib><title>Selective Destruction of Adrenal Cortex by Pulse Doses of Derivatives of 12-methylbenz(a)anthracene</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.</description><subject>Adrenal cortex</subject><subject>Adrenal Glands - drug effects</subject><subject>Animals</subject><subject>Aromatic hydrocarbons</subject><subject>Benz(a)Anthracenes - administration & dosage</subject><subject>Benz(a)Anthracenes - pharmacology</subject><subject>Biological Sciences: Medical Sciences</subject><subject>Emulsions</subject><subject>Hemorrhage</subject><subject>Hemorrhage - chemically induced</subject><subject>Hydrocarbons</subject><subject>Injections, Intravenous</subject><subject>Lipids</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Molecules</subject><subject>Necrosis</subject><subject>Rats</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFPHCEYxYlpY7fqsZemTeZSUw-zwgfDDAcPZrXVxMQmrWfCsNAdww4rMBu3f32Z7mrbiycg7_d4HzyE3hE8Jbimp6texSmHKZ3WmO2hCcGClJwJ_ApNMIa6bBiwN-htjPcYY1E1eB_tV1BxIcQE6e_GGZ26tSkuTExhyHvfF94W5_NgeuWKmQ_JPBbtpvg2uJgxH00cgQsTurUarX-OBMqlSYuNa03_67M6UX1aBKVNbw7Ra6uy9Wi3HqC7L5c_Zlflze3X69n5TalZRVLJWsB23tSUN4oozWrbtA2ba1EDbpVVBCwwUFS0zNia52cR0KRRlaWYt8DoATrb3rsa2qWZ5-gUlJOr0C1V2EivOvm_0ncL-dOvJQDlVZX9xzt_8A9D_g257KI2zqne-CHKhhEhAHgGyy2og48xGPucQbAcS5FjKZKDpDKXkvmP_w72TO9ayPqnnT7antQnu7SDc7mClLkPL3BZfr-V72Py4W-KIBzobzn2qeg</recordid><startdate>19690301</startdate><enddate>19690301</enddate><creator>Huggins, Charles</creator><creator>Morii, Sotokichi</creator><creator>Pataki, John</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19690301</creationdate><title>Selective Destruction of Adrenal Cortex by Pulse Doses of Derivatives of 12-methylbenz(a)anthracene</title><author>Huggins, Charles ; Morii, Sotokichi ; Pataki, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-4b20fd87368a1ac47f8b84dc9720bafa12f242a39b4ef7684212c18a5f306b243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Adrenal cortex</topic><topic>Adrenal Glands - drug effects</topic><topic>Animals</topic><topic>Aromatic hydrocarbons</topic><topic>Benz(a)Anthracenes - administration & dosage</topic><topic>Benz(a)Anthracenes - pharmacology</topic><topic>Biological Sciences: Medical Sciences</topic><topic>Emulsions</topic><topic>Hemorrhage</topic><topic>Hemorrhage - chemically induced</topic><topic>Hydrocarbons</topic><topic>Injections, Intravenous</topic><topic>Lipids</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Molecules</topic><topic>Necrosis</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huggins, Charles</creatorcontrib><creatorcontrib>Morii, Sotokichi</creatorcontrib><creatorcontrib>Pataki, John</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huggins, Charles</au><au>Morii, Sotokichi</au><au>Pataki, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective Destruction of Adrenal Cortex by Pulse Doses of Derivatives of 12-methylbenz(a)anthracene</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1969-03-01</date><risdate>1969</risdate><volume>62</volume><issue>3</issue><spage>704</spage><epage>707</epage><pages>704-707</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>5256999</pmid><doi>10.1073/pnas.62.3.704</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1969-03, Vol.62 (3), p.704-707 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmed_primary_5256999 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adrenal cortex Adrenal Glands - drug effects Animals Aromatic hydrocarbons Benz(a)Anthracenes - administration & dosage Benz(a)Anthracenes - pharmacology Biological Sciences: Medical Sciences Emulsions Hemorrhage Hemorrhage - chemically induced Hydrocarbons Injections, Intravenous Lipids Medical sciences Metabolism Molecules Necrosis Rats |
| title | Selective Destruction of Adrenal Cortex by Pulse Doses of Derivatives of 12-methylbenz(a)anthracene |
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