Selective Destruction of Adrenal Cortex by Pulse Doses of Derivatives of 12-methylbenz(a)anthracene

Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1969-03, Vol.62 (3), p.704-707
Hauptverfasser:	Huggins, Charles, Morii, Sotokichi, Pataki, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal cortex Adrenal Glands - drug effects Animals Aromatic hydrocarbons Benz(a)Anthracenes - administration & dosage Benz(a)Anthracenes - pharmacology Biological Sciences: Medical Sciences Emulsions Hemorrhage Hemorrhage - chemically induced Hydrocarbons Injections, Intravenous Lipids Medical sciences Metabolism Molecules Necrosis Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.62.3.704