N-Formylation of an Aromatic Amine as a Metabolic Pathway
1. Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephro-toxicity in females, caused by deposits of crystalline material in the kidney tubules. 2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of...
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| Veröffentlicht in: | Xenobiotica 1979-01, Vol.9 (9), p.533-537 |
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| container_title | Xenobiotica |
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| creator | Gothoskar, S. V. Benjamin, T. Roller, P. P. Weisburger, E. K. |
| description | 1. Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephro-toxicity in females, caused by deposits of crystalline material in the kidney tubules.
2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of urine of rats fed 2-AAQ.
3. This represents the first case of identification of the N-formyl derivative of a primary aromatic amine as a metabolite in vivo. |
| doi_str_mv | 10.3109/00498257909042318 |
| format | Article |
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2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of urine of rats fed 2-AAQ.
3. This represents the first case of identification of the N-formyl derivative of a primary aromatic amine as a metabolite in vivo.</description><identifier>ISSN: 0049-8254</identifier><identifier>EISSN: 1366-5928</identifier><identifier>DOI: 10.3109/00498257909042318</identifier><identifier>PMID: 524913</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Amines - metabolism ; Amines - toxicity ; Animals ; Anthraquinones - metabolism ; Anthraquinones - toxicity ; Body Weight - drug effects ; Female ; Formates - metabolism ; Kidney - metabolism ; Kidney - pathology ; Male ; Rats</subject><ispartof>Xenobiotica, 1979-01, Vol.9 (9), p.533-537</ispartof><rights>1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-e5199df2a7c9ade19335614acffdaf05c676851f38d07bb02f29386b88eec5c3</citedby><cites>FETCH-LOGICAL-c400t-e5199df2a7c9ade19335614acffdaf05c676851f38d07bb02f29386b88eec5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00498257909042318$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00498257909042318$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,59646,59752,60435,60541,61220,61255,61401,61436</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/524913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gothoskar, S. V.</creatorcontrib><creatorcontrib>Benjamin, T.</creatorcontrib><creatorcontrib>Roller, P. P.</creatorcontrib><creatorcontrib>Weisburger, E. K.</creatorcontrib><title>N-Formylation of an Aromatic Amine as a Metabolic Pathway</title><title>Xenobiotica</title><addtitle>Xenobiotica</addtitle><description>1. Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephro-toxicity in females, caused by deposits of crystalline material in the kidney tubules.
2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of urine of rats fed 2-AAQ.
3. This represents the first case of identification of the N-formyl derivative of a primary aromatic amine as a metabolite in vivo.</description><subject>Amines - metabolism</subject><subject>Amines - toxicity</subject><subject>Animals</subject><subject>Anthraquinones - metabolism</subject><subject>Anthraquinones - toxicity</subject><subject>Body Weight - drug effects</subject><subject>Female</subject><subject>Formates - metabolism</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Male</subject><subject>Rats</subject><issn>0049-8254</issn><issn>1366-5928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1KxDAQhYP4t64-gOBFXqA6SZo2QW-WxVVh_bnY-zJNE7ZL2yxpl6Vvb5eKIKJXw8yZ7zBzCLlmcCsY6DuAWCsuUw0aYi6YOiITJpIkkpqrYzI56NGwEJ-Ti7bdAEDCOD8jp5LHmokJ0W_Rwoe6r7ArfUO9o9jQWfD10Bs6q8vGUmwp0lfbYe6rYfiB3XqP_SU5cVi19uqrTslq8biaP0fL96eX-WwZmRigi6xkWheOY2o0FpZpIWTCYjTOFehAmiRNlGROqALSPAfuuBYqyZWy1kgjpoSNtib4tg3WZdtQ1hj6jEF2yCD7lcHA3IzMdpfXtvgmxqcH-WGUy8YNv-Peh6rIOuwrH1zAxpTtwflv9_sf-Npi1a0NBptt_C40Qxj_3PYJd4N7Ag</recordid><startdate>19790101</startdate><enddate>19790101</enddate><creator>Gothoskar, S. V.</creator><creator>Benjamin, T.</creator><creator>Roller, P. P.</creator><creator>Weisburger, E. K.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19790101</creationdate><title>N-Formylation of an Aromatic Amine as a Metabolic Pathway</title><author>Gothoskar, S. V. ; Benjamin, T. ; Roller, P. P. ; Weisburger, E. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-e5199df2a7c9ade19335614acffdaf05c676851f38d07bb02f29386b88eec5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Amines - metabolism</topic><topic>Amines - toxicity</topic><topic>Animals</topic><topic>Anthraquinones - metabolism</topic><topic>Anthraquinones - toxicity</topic><topic>Body Weight - drug effects</topic><topic>Female</topic><topic>Formates - metabolism</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Male</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gothoskar, S. V.</creatorcontrib><creatorcontrib>Benjamin, T.</creatorcontrib><creatorcontrib>Roller, P. P.</creatorcontrib><creatorcontrib>Weisburger, E. K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Xenobiotica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gothoskar, S. V.</au><au>Benjamin, T.</au><au>Roller, P. P.</au><au>Weisburger, E. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-Formylation of an Aromatic Amine as a Metabolic Pathway</atitle><jtitle>Xenobiotica</jtitle><addtitle>Xenobiotica</addtitle><date>1979-01-01</date><risdate>1979</risdate><volume>9</volume><issue>9</issue><spage>533</spage><epage>537</epage><pages>533-537</pages><issn>0049-8254</issn><eissn>1366-5928</eissn><abstract>1. Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephro-toxicity in females, caused by deposits of crystalline material in the kidney tubules.
2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of urine of rats fed 2-AAQ.
3. This represents the first case of identification of the N-formyl derivative of a primary aromatic amine as a metabolite in vivo.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>524913</pmid><doi>10.3109/00498257909042318</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-8254 |
| ispartof | Xenobiotica, 1979-01, Vol.9 (9), p.533-537 |
| issn | 0049-8254 1366-5928 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Amines - metabolism Amines - toxicity Animals Anthraquinones - metabolism Anthraquinones - toxicity Body Weight - drug effects Female Formates - metabolism Kidney - metabolism Kidney - pathology Male Rats |
| title | N-Formylation of an Aromatic Amine as a Metabolic Pathway |
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