N-Formylation of an Aromatic Amine as a Metabolic Pathway

N-Formylation of an Aromatic Amine as a Metabolic Pathway

1. Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephro-toxicity in females, caused by deposits of crystalline material in the kidney tubules. 2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of...

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Veröffentlicht in:Xenobiotica 1979-01, Vol.9 (9), p.533-537
Hauptverfasser: Gothoskar, S. V., Benjamin, T., Roller, P. P., Weisburger, E. K.
Format: Artikel
Sprache:eng
Schlagworte:
Amines - metabolism
Amines - toxicity
Animals
Anthraquinones - metabolism
Anthraquinones - toxicity
Body Weight - drug effects
Female
Formates - metabolism
Kidney - metabolism
Kidney - pathology
Male
Rats
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Zusammenfassung:1. Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephro-toxicity in females, caused by deposits of crystalline material in the kidney tubules. 2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of urine of rats fed 2-AAQ. 3. This represents the first case of identification of the N-formyl derivative of a primary aromatic amine as a metabolite in vivo.
ISSN:0049-8254
1366-5928
DOI:10.3109/00498257909042318