Chlorpromazine and the eye of the dog: V. Attempt to Produce Lenticular Lesions

Administration of chlorpromazine hydrochloride at a maximum-tolerated dose for approximately 2 years caused an increase in the corneal stromal deposits that existed after 7 months of treatment. However, further administration, at the same high level of dosing, did not produce granular deposits in or...

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Veröffentlicht in:	Experimental and molecular pathology 1972, Vol.16 (2), p.169-171
Hauptverfasser:	Barron, C.N, Rubin, L.F, Steelman, R.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral animal science Animals Chlorpromazine - administration & dosage Chlorpromazine - toxicity Cornea - cytology Cornea - drug effects Cytoplasmic Granules Depression - chemically induced Dogs Eye Diseases - chemically induced Female Humans Lens, Crystalline - drug effects livestock Male Salivation Vomiting - chemically induced zoology
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Zusammenfassung:	Administration of chlorpromazine hydrochloride at a maximum-tolerated dose for approximately 2 years caused an increase in the corneal stromal deposits that existed after 7 months of treatment. However, further administration, at the same high level of dosing, did not produce granular deposits in or on the lens of the dog.
ISSN:	0014-4800 1096-0945
DOI:	10.1016/0014-4800(72)90031-7