Effect of a New Anti-Inflammatory Drug, Fenoprofen, on Platelet Aggregation and Thrombus Formation
Summary Fenoprofen sodium (a new antiinflammatory drug), aspirin, and phenylbutazone were compared with respect to their inhibitory activity on platelet function. These compounds inhibit collagen-induced platelet aggregation both in vitro (human, rabbit, and guinea pig) and in vivo (rabbit and guine...
Gespeichert in:
| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1972-02, Vol.139 (2), p.548-552 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 552 |
|---|---|
| container_issue | 2 |
| container_start_page | 548 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 139 |
| creator | Herrmann, Roy G. Marshall, W. S. Crowe, V. Gail Frank, J. D. Marlett, D. L. Lacefield, W. B. |
| description | Summary
Fenoprofen sodium (a new antiinflammatory drug), aspirin, and phenylbutazone were compared with respect to their inhibitory activity on platelet function. These compounds inhibit collagen-induced platelet aggregation both in vitro (human, rabbit, and guinea pig) and in vivo (rabbit and guinea pig).
In an extracorporeal shunt experiment in the rabbit, both fenoprofen sodium and aspirin inhibited thrombus formation.
Of the three compounds tested, fenoprofen sodium appears to be the most active inhibitor of platelet function. |
| doi_str_mv | 10.3181/00379727-139-36183 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_pubmed_primary_5059045</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3181_00379727-139-36183</sage_id><sourcerecordid>10.3181_00379727-139-36183</sourcerecordid><originalsourceid>FETCH-LOGICAL-c338t-a89da2ed9ae5fb97384787654ebb156e06d4f79a23b5c29c720cbd9c321780fd3</originalsourceid><addsrcrecordid>eNp9kFtLwzAUx4Moc06_gCDkA6wul6ZpHsfcdDDUh_lckvakbrTNSFpk337dRR99Opzzv8D5IfRIyTOnKZ0QwqWSTEaUq4gnNOVXaEgFF_2i1DUaHg3R0XGL7kLYEkKFZMkADQQRisRiiMzcWshb7CzW-B1-8LRpN9GysZWua906v8cvvivHeAGN23lnoRlj1-DPSrdQQYunZemh1O2mP-qmwOtv72rTBbxwvj6d79GN1VWAh8scoa_FfD17i1Yfr8vZdBXlnKdtpFNVaAaF0iCsUZKnsUxlImIwhooESFLEVirNuBE5U7lkJDeFyjmjMiW24CPEzr25dyF4sNnOb2rt9xkl2ZFX9ssr63llJ1596Okc2nWmhuIvcgHU65OzHnQJ2dZ1vul_-K_xAOCUc60</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effect of a New Anti-Inflammatory Drug, Fenoprofen, on Platelet Aggregation and Thrombus Formation</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Herrmann, Roy G. ; Marshall, W. S. ; Crowe, V. Gail ; Frank, J. D. ; Marlett, D. L. ; Lacefield, W. B.</creator><creatorcontrib>Herrmann, Roy G. ; Marshall, W. S. ; Crowe, V. Gail ; Frank, J. D. ; Marlett, D. L. ; Lacefield, W. B.</creatorcontrib><description>Summary
Fenoprofen sodium (a new antiinflammatory drug), aspirin, and phenylbutazone were compared with respect to their inhibitory activity on platelet function. These compounds inhibit collagen-induced platelet aggregation both in vitro (human, rabbit, and guinea pig) and in vivo (rabbit and guinea pig).
In an extracorporeal shunt experiment in the rabbit, both fenoprofen sodium and aspirin inhibited thrombus formation.
Of the three compounds tested, fenoprofen sodium appears to be the most active inhibitor of platelet function.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-139-36183</identifier><identifier>PMID: 5059045</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adenosine Diphosphate - antagonists & inhibitors ; Analysis of Variance ; Animals ; Anti-Inflammatory Agents - pharmacology ; Aspirin - pharmacology ; Blood Platelets - drug effects ; Collagen - antagonists & inhibitors ; Depression, Chemical ; Drug Antagonism ; Ethers - pharmacology ; Extracorporeal Circulation ; Humans ; In Vitro Techniques ; Mesentery - blood supply ; Microcirculation - drug effects ; Phenylbutazone - pharmacology ; Platelet Adhesiveness - drug effects ; Propionates - pharmacology ; Rabbits ; Thrombosis - prevention & control</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1972-02, Vol.139 (2), p.548-552</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-a89da2ed9ae5fb97384787654ebb156e06d4f79a23b5c29c720cbd9c321780fd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5059045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herrmann, Roy G.</creatorcontrib><creatorcontrib>Marshall, W. S.</creatorcontrib><creatorcontrib>Crowe, V. Gail</creatorcontrib><creatorcontrib>Frank, J. D.</creatorcontrib><creatorcontrib>Marlett, D. L.</creatorcontrib><creatorcontrib>Lacefield, W. B.</creatorcontrib><title>Effect of a New Anti-Inflammatory Drug, Fenoprofen, on Platelet Aggregation and Thrombus Formation</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Fenoprofen sodium (a new antiinflammatory drug), aspirin, and phenylbutazone were compared with respect to their inhibitory activity on platelet function. These compounds inhibit collagen-induced platelet aggregation both in vitro (human, rabbit, and guinea pig) and in vivo (rabbit and guinea pig).
In an extracorporeal shunt experiment in the rabbit, both fenoprofen sodium and aspirin inhibited thrombus formation.
Of the three compounds tested, fenoprofen sodium appears to be the most active inhibitor of platelet function.</description><subject>Adenosine Diphosphate - antagonists & inhibitors</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Aspirin - pharmacology</subject><subject>Blood Platelets - drug effects</subject><subject>Collagen - antagonists & inhibitors</subject><subject>Depression, Chemical</subject><subject>Drug Antagonism</subject><subject>Ethers - pharmacology</subject><subject>Extracorporeal Circulation</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Mesentery - blood supply</subject><subject>Microcirculation - drug effects</subject><subject>Phenylbutazone - pharmacology</subject><subject>Platelet Adhesiveness - drug effects</subject><subject>Propionates - pharmacology</subject><subject>Rabbits</subject><subject>Thrombosis - prevention & control</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLwzAUx4Moc06_gCDkA6wul6ZpHsfcdDDUh_lckvakbrTNSFpk337dRR99Opzzv8D5IfRIyTOnKZ0QwqWSTEaUq4gnNOVXaEgFF_2i1DUaHg3R0XGL7kLYEkKFZMkADQQRisRiiMzcWshb7CzW-B1-8LRpN9GysZWua906v8cvvivHeAGN23lnoRlj1-DPSrdQQYunZemh1O2mP-qmwOtv72rTBbxwvj6d79GN1VWAh8scoa_FfD17i1Yfr8vZdBXlnKdtpFNVaAaF0iCsUZKnsUxlImIwhooESFLEVirNuBE5U7lkJDeFyjmjMiW24CPEzr25dyF4sNnOb2rt9xkl2ZFX9ssr63llJ1596Okc2nWmhuIvcgHU65OzHnQJ2dZ1vul_-K_xAOCUc60</recordid><startdate>197202</startdate><enddate>197202</enddate><creator>Herrmann, Roy G.</creator><creator>Marshall, W. S.</creator><creator>Crowe, V. Gail</creator><creator>Frank, J. D.</creator><creator>Marlett, D. L.</creator><creator>Lacefield, W. B.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197202</creationdate><title>Effect of a New Anti-Inflammatory Drug, Fenoprofen, on Platelet Aggregation and Thrombus Formation</title><author>Herrmann, Roy G. ; Marshall, W. S. ; Crowe, V. Gail ; Frank, J. D. ; Marlett, D. L. ; Lacefield, W. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-a89da2ed9ae5fb97384787654ebb156e06d4f79a23b5c29c720cbd9c321780fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Adenosine Diphosphate - antagonists & inhibitors</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Aspirin - pharmacology</topic><topic>Blood Platelets - drug effects</topic><topic>Collagen - antagonists & inhibitors</topic><topic>Depression, Chemical</topic><topic>Drug Antagonism</topic><topic>Ethers - pharmacology</topic><topic>Extracorporeal Circulation</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Mesentery - blood supply</topic><topic>Microcirculation - drug effects</topic><topic>Phenylbutazone - pharmacology</topic><topic>Platelet Adhesiveness - drug effects</topic><topic>Propionates - pharmacology</topic><topic>Rabbits</topic><topic>Thrombosis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herrmann, Roy G.</creatorcontrib><creatorcontrib>Marshall, W. S.</creatorcontrib><creatorcontrib>Crowe, V. Gail</creatorcontrib><creatorcontrib>Frank, J. D.</creatorcontrib><creatorcontrib>Marlett, D. L.</creatorcontrib><creatorcontrib>Lacefield, W. B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herrmann, Roy G.</au><au>Marshall, W. S.</au><au>Crowe, V. Gail</au><au>Frank, J. D.</au><au>Marlett, D. L.</au><au>Lacefield, W. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a New Anti-Inflammatory Drug, Fenoprofen, on Platelet Aggregation and Thrombus Formation</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1972-02</date><risdate>1972</risdate><volume>139</volume><issue>2</issue><spage>548</spage><epage>552</epage><pages>548-552</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Fenoprofen sodium (a new antiinflammatory drug), aspirin, and phenylbutazone were compared with respect to their inhibitory activity on platelet function. These compounds inhibit collagen-induced platelet aggregation both in vitro (human, rabbit, and guinea pig) and in vivo (rabbit and guinea pig).
In an extracorporeal shunt experiment in the rabbit, both fenoprofen sodium and aspirin inhibited thrombus formation.
Of the three compounds tested, fenoprofen sodium appears to be the most active inhibitor of platelet function.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5059045</pmid><doi>10.3181/00379727-139-36183</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1972-02, Vol.139 (2), p.548-552 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_pubmed_primary_5059045 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenosine Diphosphate - antagonists & inhibitors Analysis of Variance Animals Anti-Inflammatory Agents - pharmacology Aspirin - pharmacology Blood Platelets - drug effects Collagen - antagonists & inhibitors Depression, Chemical Drug Antagonism Ethers - pharmacology Extracorporeal Circulation Humans In Vitro Techniques Mesentery - blood supply Microcirculation - drug effects Phenylbutazone - pharmacology Platelet Adhesiveness - drug effects Propionates - pharmacology Rabbits Thrombosis - prevention & control |
| title | Effect of a New Anti-Inflammatory Drug, Fenoprofen, on Platelet Aggregation and Thrombus Formation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A10%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sage_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20a%20New%20Anti-Inflammatory%20Drug,%20Fenoprofen,%20on%20Platelet%20Aggregation%20and%20Thrombus%20Formation&rft.jtitle=Experimental%20biology%20and%20medicine%20(Maywood,%20N.J.)&rft.au=Herrmann,%20Roy%20G.&rft.date=1972-02&rft.volume=139&rft.issue=2&rft.spage=548&rft.epage=552&rft.pages=548-552&rft.issn=0037-9727&rft.eissn=1535-3699&rft_id=info:doi/10.3181/00379727-139-36183&rft_dat=%3Csage_cross%3E10.3181_00379727-139-36183%3C/sage_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/5059045&rft_sage_id=10.3181_00379727-139-36183&rfr_iscdi=true |