Effect of a New Anti-Inflammatory Drug, Fenoprofen, on Platelet Aggregation and Thrombus Formation

Summary Fenoprofen sodium (a new antiinflammatory drug), aspirin, and phenylbutazone were compared with respect to their inhibitory activity on platelet function. These compounds inhibit collagen-induced platelet aggregation both in vitro (human, rabbit, and guinea pig) and in vivo (rabbit and guinea pig). In an extracorporeal shunt experiment in the rabbit, both fenoprofen sodium and aspirin inhibited thrombus formation. Of the three compounds tested, fenoprofen sodium appears to be the most active inhibitor of platelet function.