Effect of Aflatoxin on Complement Activity in Guinea Pigs

Summary Guinea pigs were dosed once daily with partially purifed aflatoxin in measured amounts per os for 20 days. A significant average depression of complement titers occurred in guinea pigs given a daily dose of aflatoxin equivalent to 0.03 mg or greater of fraction B1. Guinea pigs given a daily...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1972-01, Vol.139 (1), p.300-303
Hauptverfasser:	Thurston, John R., Richard, John L., Cysewski, Sigmund J., Pier, Allan C., Graham, Charles K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxins - pharmacology Aflatoxins - toxicity Analysis of Variance Animals Body Weight - drug effects Chemical and Drug Induced Liver Injury Complement Inactivator Proteins Complement System Proteins - analysis Drug Antagonism Female Guinea Pigs Immunosuppressive Agents - pharmacology Liver - drug effects Liver Diseases - pathology
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Beschreibung
Zusammenfassung:	Summary Guinea pigs were dosed once daily with partially purifed aflatoxin in measured amounts per os for 20 days. A significant average depression of complement titers occurred in guinea pigs given a daily dose of aflatoxin equivalent to 0.03 mg or greater of fraction B1. Guinea pigs given a daily dose of aflatoxin equivalent to 0.01 5 mg or greater of fraction B1 had average weight significantly below that of control guinea pigs. Microscopic changes in the liver were detected mostly in guinea pigs given 0.03 mg or more of B1 equivalents. Considerable individual variation in complement titers, weights, and liver changes were noted among the guinea pigs.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-139-36130