Doxantrazole, an antiallergic agent orally effective in man

In-vivo studies have demonstrated antiallergic properties in doxantrazole when given orally to rats. These properties were confirmed in work with in-vitro preparations. No significant animal toxicity has been detected. 200 mg. given by mouth inhibited the immediate-type asthmatic response in volunte...

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Veröffentlicht in:	The Lancet (British edition) 1975-05, Vol.1 (7917), p.1169
Hauptverfasser:	Batchelor, J F, Follenfant, M J, Garland, L G, Gorvin, J H, Green, A F, Hodson, H F, Hughes, D T, Tateson, J E
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Asthma - drug therapy Drug Evaluation Drug Evaluation, Preclinical Histamine Release - drug effects Humans In Vitro Techniques Rats Tetrazoles - administration & dosage Tetrazoles - pharmacology Tetrazoles - therapeutic use Thioxanthenes - administration & dosage Thioxanthenes - pharmacology Thioxanthenes - therapeutic use
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Beschreibung
Zusammenfassung:	In-vivo studies have demonstrated antiallergic properties in doxantrazole when given orally to rats. These properties were confirmed in work with in-vitro preparations. No significant animal toxicity has been detected. 200 mg. given by mouth inhibited the immediate-type asthmatic response in volunteer patients challenged with specific antigen.
ISSN:	0140-6736