Passive Hemolytic Antibody Response of Primed, Partially Resistant Mice to Heat-Killed Salmonella typhimurium Vaccine

Summary Mean effective doses (50% protection) of S. typhimurium heat-killed, alcohol-treated bacterial vaccine depended upon the interval before challenge at which the single dose was given. Circulating antibody response against the lipopolysaccharide component of the organism appeared to be related...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1968-06, Vol.128 (2), p.419-423
1. Verfasser:	Ransom, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Antigen-Antibody Reactions Bacterial Vaccines - administration & dosage Methods Mice Salmonella typhimurium - immunology Serologic Tests
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Beschreibung
Zusammenfassung:	Summary Mean effective doses (50% protection) of S. typhimurium heat-killed, alcohol-treated bacterial vaccine depended upon the interval before challenge at which the single dose was given. Circulating antibody response against the lipopolysaccharide component of the organism appeared to be related to the magnitude of the mean effective dose, but not to the partial immunity developed. Killed vaccine was an effective immunizing agent if given at an optimal time interval before challenge.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-128-33027