BIOSYNTHESIS OF LASALOCID. I: INCORPORATION OF 13C AND 14C LABELLED SUBSTRATES INTO LASALOCID A

BIOSYNTHESIS OF LASALOCID. I: INCORPORATION OF 13C AND 14C LABELLED SUBSTRATES INTO LASALOCID A

The biosynthesis of lasalocid A (formerly antibiotic X-537 A) in cultures of Strepto-myces lasaliensis has been studied using 13C- and 14C-labelled precursors. The antibiotic is derived from five acetate, four propionate and three butyrate units. This study has provided the first illustration of an...

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Veröffentlicht in:Journal of antibiotics 1974, Vol.27(4), pp.288-297
Hauptverfasser: WESTLEY, J. W., EVANS, R. H. Jr, HARVEY, G., PITCHER, R. G., PRUESS, D. L., STEMPEL, A., BERGER, J.
Format: Artikel
Sprache:eng
Schlagworte:
Acetates - metabolism
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Butyrates - metabolism
Carbon Isotopes
Carbon Radioisotopes
Chemical Phenomena
Chemistry
Propionates - metabolism
Streptomyces - metabolism
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Zusammenfassung:The biosynthesis of lasalocid A (formerly antibiotic X-537 A) in cultures of Strepto-myces lasaliensis has been studied using 13C- and 14C-labelled precursors. The antibiotic is derived from five acetate, four propionate and three butyrate units. This study has provided the first illustration of an ethyl group arising from butyrate and 2-ethylmalonate.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.27.288