ENHANCEMENT OF RADIATION EFFECT ON TRANSFORMED FIBROBLASTIC CELLS BY A SYNERGISTIC COMBINATION OF 5-FLUOROURACIL AND POLYENES IN VITRO

ENHANCEMENT OF RADIATION EFFECT ON TRANSFORMED FIBROBLASTIC CELLS BY A SYNERGISTIC COMBINATION OF 5-FLUOROURACIL AND POLYENES IN VITRO

Using cultured transformed fibroblasts (RFL-T), an antitumor agent, 5-fluorouracil, was found to be potentiated in its inhibitory action on RNA formation by vitamin A as well as Amphotericin-B. 5-Fluorouracil in combination with vitamin A or Amphotericin-B enhanced more effectively the cellular sens...

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Veröffentlicht in:GANN Japanese Journal of Cancer Research 1974/02/28, Vol.65(1), pp.85-87
Hauptverfasser: KOMIYAMA, Sohtaro, HIROTO, Ikuichiro, KUWANO, Michihiko, ENDO, Hideya, KOGA, Kenji
Format: Artikel
Sprache:eng
Schlagworte:
5-Fluorouracil
Amphotericin B - pharmacology
Animals
Carbon Radioisotopes
Cells, Cultured
Drug Synergism
Fibroblast, rat
Fibroblasts - drug effects
Fibroblasts - radiation effects
Fluorouracil - pharmacology
Gross leukemia virus
Polyenes
Polyenes - pharmacology
Radiation Dosage
Radiation effect, in vitro
Radiation Effects
Radiation-Sensitizing Agents
Rats
RNA - metabolism
Uridine - metabolism
Vitamin A - pharmacology
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Zusammenfassung:Using cultured transformed fibroblasts (RFL-T), an antitumor agent, 5-fluorouracil, was found to be potentiated in its inhibitory action on RNA formation by vitamin A as well as Amphotericin-B. 5-Fluorouracil in combination with vitamin A or Amphotericin-B enhanced more effectively the cellular sensitivity to cobalt radiation than when 5-fluorouracil was used alone.
ISSN:0016-450X
DOI:10.20772/cancersci1959.65.1_85