ANTITUMOR ACTIVITY OF HALOACETYLCARBAZOLE DERIVATIVES

Antitumor activity of the newly synthesized haloacetyl derivalives of carbazole, phenoxsazine, acridine, oriminodibenzyl was examined on ascites sarcoma-180. lodoacetylcarbazole was the most active and its therapeutic index was 26. Carbazole ring and bromocr iodo-acetyl groups were suitable for the...

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Veröffentlicht in:	GANN Japanese Journal of Cancer Research 1973/08/31, Vol.64(4), pp.391-396
Hauptverfasser:	KANZAWA, Fumihiko, HOSHI, Akio, OHMINE, Mihoko, KURETANI, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Carbazoles - therapeutic use Carbazoles - toxicity Female Halogens Lethal Dose 50 Mice Phenothiazines - therapeutic use Sarcoma 180 - drug therapy Structure-Activity Relationship
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Zusammenfassung:	Antitumor activity of the newly synthesized haloacetyl derivalives of carbazole, phenoxsazine, acridine, oriminodibenzyl was examined on ascites sarcoma-180. lodoacetylcarbazole was the most active and its therapeutic index was 26. Carbazole ring and bromocr iodo-acetyl groups were suitable for the antitumor activity among the ring systems and side chains.
ISSN:	0016-450X
DOI:	10.20772/cancersci1959.64.4_391