Alterations in DMBA-Induced Rat Mammary Tumors by Actinomycin D

Actinomycin D not only protected against the induction of rat mammary tumors by 7,12-dimethylbenz[a]anthracene, but also influenced the nature of those tumors that developed. Fewer glandular neoplasms, and more secretory adenomas and fibroadenomas were formed. Histologic distinctions among the vario...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1973-04, Vol.50 (4), p.915-920
Hauptverfasser:	Gardner, H. Allen, Kellen, J. A., Anderson, K. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenofibroma - chemically induced Adenofibroma - pathology Adenoma - chemically induced Adenoma - pathology Animals Benz(a)Anthracenes Dactinomycin - therapeutic use Female Fibroma - chemically induced Fibroma - pathology Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - prevention & control Rats
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Zusammenfassung:	Actinomycin D not only protected against the induction of rat mammary tumors by 7,12-dimethylbenz[a]anthracene, but also influenced the nature of those tumors that developed. Fewer glandular neoplasms, and more secretory adenomas and fibroadenomas were formed. Histologic distinctions among the various mammary nodules are described, and it is stressed that evaluation of experimental data without consideration of the histologic nature of the nodules may be invalid.
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/50.4.915