Malignant Melanoma: Specific Immunity Induced by Bacillus Calmette-Guérin in BALB/c Mice

Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1974-07, Vol.185 (4145), p.68-69
Hauptverfasser:	Faraci, Robert P., Schour, Lionel
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins Animals Antibodies, Bacterial - analysis Antibodies, Neoplasm - analysis Antilymphocyte Serum BCG Vaccine Carcinoma Carcinoma - prevention & control Cell Line Cytotoxicity Cytotoxicity Tests, Immunologic Immunity Immunology Lymphocytes Lymphocytes - immunology Mammary Neoplasms, Experimental - prevention & control Melanoma Melanoma - immunology Melanoma - prevention & control Methylcholanthrene Mice Mice, Inbred BALB C Mycobacterium bovis - immunology Neoplasm Transplantation Noma Sarcoma Sarcoma, Experimental - chemically induced Sarcoma, Experimental - prevention & control Transplantation, Homologous Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in showing that BCG-immune lymphocytes are specifically cytotoxic to S-91 melanoma target cells but not to the carcinoma or sarcoma target cells.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.185.4145.68