Treatment of Urinary Tract Infections with a Sulphamethoxazole Trimethoprim Compound: A Controlled, Double Blind, Clinical Trial

Abstract In a double blind study 69 patients with urinary tract infection (86 bacterial strains) were treated with sulphamethoxazole plus trimethoprim ***(5 : 1) for 6 days. The cure rate was 92%. A comparable control group of 71 patients (91 bacterial strains) was treated with sulphamethoxazole in the same dose. The cure rate was 64%. Follow-up 14 days after treatment showed cure rates of 66 and 39%, respectively. The differences are statistically significant. The frequency of relapses was the same in the two groups of treatment. Side effects were few and corresponded to what is commonly found in single therapy with sulphonamide.