RAPID AND SELECTIVE INDUCTION OF ERYTHROLEUKEMIA IN FEMALE DONRYU RATS BY 1-ETHYL-1-NITROSOUREA

Thirty-five female Donryu rats were given continuously 400-ppm solution of 1-ethyl-1-nitro-ourea as their drinking water. Among them, 34 rats (97%) developed erythroleukemia beween 70 and 113 experimental days, 86.4±10.4 days in the average. No other tumors were letected in any of them.

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Bibliographische Detailangaben
Veröffentlicht in:	GANN Japanese Journal of Cancer Research 1974/08/31, Vol.65(4), pp.377-377
Hauptverfasser:	OGIU, Toshiaki, NAKADATE, Masahiro, ODASHIMA, Shigeyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Ethyl-1-nitrosourea Administration, Oral Animals Carcinogens Donryu rat Erythroleukemia Female Hepatomegaly - chemically induced Leukemia, Erythroblastic, Acute - chemically induced Leukemia, Myeloid, Acute - chemically induced Leukemogenesis Nitrosourea Compounds Rats Splenomegaly - chemically induced Water
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Beschreibung
Zusammenfassung:	Thirty-five female Donryu rats were given continuously 400-ppm solution of 1-ethyl-1-nitro-ourea as their drinking water. Among them, 34 rats (97%) developed erythroleukemia beween 70 and 113 experimental days, 86.4±10.4 days in the average. No other tumors were letected in any of them.
ISSN:	0016-450X
DOI:	10.20772/cancersci1959.65.4_377