EFFECT OF GLUCOSE IN ISOPROTERENOL-INDUCED NECROTIC HEART UNDER ANOXIC PERFUSION

Studies of the isoproterenol-induced necrotic heart perfused under an anoxic condition were performed to determine the changes of metabolism and mechanical function. It was found that the increased concentration of glucose in a perfusion medium enabled the necrotic heart to preserve mechanical funct...

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Veröffentlicht in:	Japanese journal of pharmacology 1974, Vol.24(5), pp.803-808
Hauptverfasser:	TSUBOI, Toshimichi, OHSAWA, Yoshiko, ISHIKAWA, Kohsaku, YOSHIDA, Kouichi, SHIMIZU, Masanao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analysis Animals Glucose - pharmacology Glycogen - analysis Heart - physiopathology Heart Diseases - chemically induced Heart Diseases - physiopathology Hypoxia - metabolism Isoproterenol Lactates - analysis Lactates - metabolism Male Myocardium - analysis Myocardium - metabolism Necrosis - chemically induced Perfusion Phosphocreatine - analysis Rats Time Factors
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Zusammenfassung:	Studies of the isoproterenol-induced necrotic heart perfused under an anoxic condition were performed to determine the changes of metabolism and mechanical function. It was found that the increased concentration of glucose in a perfusion medium enabled the necrotic heart to preserve mechanical functions during anoxia. However, in the normal heart the protective effect of high glucose concentration was not significant. High glucose concentration enhanced anaerobic glycolysis in the necrotic heart during anoxia but had no significant effect on the levels of myocardial high energy phosphates.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.24.803