Differential Effects of Salmon, Porcine, and Human Calcitonin on Gastric Secretion and Gastric Emptying in Rats
Summary The effects of PCT, SCT, and HCT were studied on gastric acid secretion in pylorus-ligated rats and gastric emptying in normal rats. Volume and acidity of gastric secretion were inhibited in a dose-dependent manner by all three preparations; however, HCT was markedly less potent than SCT or...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1974-10, Vol.147 (1), p.284-288 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 147 |
| creator | Bobalik, G. R. Kleszynski, R. R. Aldred, J. P. Bastian, J. W. |
| description | Summary
The effects of PCT, SCT, and HCT were studied on gastric acid secretion in pylorus-ligated rats and gastric emptying in normal rats. Volume and acidity of gastric secretion were inhibited in a dose-dependent manner by all three preparations; however, HCT was markedly less potent than SCT or PCT when comparisons were based on equal hypocalcemic potencies. Similar results were obtained, including the lesser effect of HCT, in studies on inhibition of gastric emptying involving the administration of an Evan's blue test meal. These gastric effects of calcitonin appear not to be mediated by changes in serum calcium. |
| doi_str_mv | 10.3181/00379727-147-38327 |
| format | Article |
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The effects of PCT, SCT, and HCT were studied on gastric acid secretion in pylorus-ligated rats and gastric emptying in normal rats. Volume and acidity of gastric secretion were inhibited in a dose-dependent manner by all three preparations; however, HCT was markedly less potent than SCT or PCT when comparisons were based on equal hypocalcemic potencies. Similar results were obtained, including the lesser effect of HCT, in studies on inhibition of gastric emptying involving the administration of an Evan's blue test meal. These gastric effects of calcitonin appear not to be mediated by changes in serum calcium.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-147-38327</identifier><identifier>PMID: 4438335</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Calcitonin - administration & dosage ; Calcitonin - pharmacology ; Gastric Acidity Determination ; Gastric Juice - metabolism ; Humans ; Hypocalcemia - chemically induced ; Injections, Subcutaneous ; Male ; Rats ; Salmon ; Stomach - drug effects ; Stomach - physiology ; Swine</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1974-10, Vol.147 (1), p.284-288</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-307f569ecadbf6c075fc220563698065565f51f9928bdca689aae6b6f2a6527b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4438335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bobalik, G. R.</creatorcontrib><creatorcontrib>Kleszynski, R. R.</creatorcontrib><creatorcontrib>Aldred, J. P.</creatorcontrib><creatorcontrib>Bastian, J. W.</creatorcontrib><title>Differential Effects of Salmon, Porcine, and Human Calcitonin on Gastric Secretion and Gastric Emptying in Rats</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
The effects of PCT, SCT, and HCT were studied on gastric acid secretion in pylorus-ligated rats and gastric emptying in normal rats. Volume and acidity of gastric secretion were inhibited in a dose-dependent manner by all three preparations; however, HCT was markedly less potent than SCT or PCT when comparisons were based on equal hypocalcemic potencies. Similar results were obtained, including the lesser effect of HCT, in studies on inhibition of gastric emptying involving the administration of an Evan's blue test meal. These gastric effects of calcitonin appear not to be mediated by changes in serum calcium.</description><subject>Animals</subject><subject>Calcitonin - administration & dosage</subject><subject>Calcitonin - pharmacology</subject><subject>Gastric Acidity Determination</subject><subject>Gastric Juice - metabolism</subject><subject>Humans</subject><subject>Hypocalcemia - chemically induced</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Rats</subject><subject>Salmon</subject><subject>Stomach - drug effects</subject><subject>Stomach - physiology</subject><subject>Swine</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9KAzEQh4MotVZfQBDyAF2bP5tk9yi1tkJBsXpestmkpOwmJdke-vZmbfXoaYaZ7zcwHwD3GD1SXOAZQlSUgogM5yKjBSXiAowxoyyjvCwvwXgAsoG4Bjcx7hDCTBA-AqM8TzhlY-CfrTE6aNdb2cJF6lUfoTdwI9vOuyl890FZp6dQugauDp10cC5bZXvvrIPewaWMfbAKbrQKurdpMpC_00W374_WbWGCP2Qfb8GVkW3Ud-c6AV8vi8_5Klu_LV_nT-tM5SjvM4qEYbzUSja14QoJZhQhiPH0WIE4Y5wZhk1ZkqJulORFKaXmNTdEckZETSeAnO6q4GMM2lT7YDsZjhVG1SCv-pVXJXnVj7wUejiF9oe6081f5Gwr7WenfZRbXe38Ibj0w38XvwGlDnfr</recordid><startdate>197410</startdate><enddate>197410</enddate><creator>Bobalik, G. R.</creator><creator>Kleszynski, R. R.</creator><creator>Aldred, J. P.</creator><creator>Bastian, J. W.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197410</creationdate><title>Differential Effects of Salmon, Porcine, and Human Calcitonin on Gastric Secretion and Gastric Emptying in Rats</title><author>Bobalik, G. R. ; Kleszynski, R. R. ; Aldred, J. P. ; Bastian, J. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-307f569ecadbf6c075fc220563698065565f51f9928bdca689aae6b6f2a6527b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Calcitonin - administration & dosage</topic><topic>Calcitonin - pharmacology</topic><topic>Gastric Acidity Determination</topic><topic>Gastric Juice - metabolism</topic><topic>Humans</topic><topic>Hypocalcemia - chemically induced</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Rats</topic><topic>Salmon</topic><topic>Stomach - drug effects</topic><topic>Stomach - physiology</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bobalik, G. R.</creatorcontrib><creatorcontrib>Kleszynski, R. R.</creatorcontrib><creatorcontrib>Aldred, J. P.</creatorcontrib><creatorcontrib>Bastian, J. W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bobalik, G. R.</au><au>Kleszynski, R. R.</au><au>Aldred, J. P.</au><au>Bastian, J. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Effects of Salmon, Porcine, and Human Calcitonin on Gastric Secretion and Gastric Emptying in Rats</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1974-10</date><risdate>1974</risdate><volume>147</volume><issue>1</issue><spage>284</spage><epage>288</epage><pages>284-288</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
The effects of PCT, SCT, and HCT were studied on gastric acid secretion in pylorus-ligated rats and gastric emptying in normal rats. Volume and acidity of gastric secretion were inhibited in a dose-dependent manner by all three preparations; however, HCT was markedly less potent than SCT or PCT when comparisons were based on equal hypocalcemic potencies. Similar results were obtained, including the lesser effect of HCT, in studies on inhibition of gastric emptying involving the administration of an Evan's blue test meal. These gastric effects of calcitonin appear not to be mediated by changes in serum calcium.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>4438335</pmid><doi>10.3181/00379727-147-38327</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1974-10, Vol.147 (1), p.284-288 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_pubmed_primary_4438335 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Calcitonin - administration & dosage Calcitonin - pharmacology Gastric Acidity Determination Gastric Juice - metabolism Humans Hypocalcemia - chemically induced Injections, Subcutaneous Male Rats Salmon Stomach - drug effects Stomach - physiology Swine |
| title | Differential Effects of Salmon, Porcine, and Human Calcitonin on Gastric Secretion and Gastric Emptying in Rats |
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