Differential Effects of Salmon, Porcine, and Human Calcitonin on Gastric Secretion and Gastric Emptying in Rats

Summary The effects of PCT, SCT, and HCT were studied on gastric acid secretion in pylorus-ligated rats and gastric emptying in normal rats. Volume and acidity of gastric secretion were inhibited in a dose-dependent manner by all three preparations; however, HCT was markedly less potent than SCT or PCT when comparisons were based on equal hypocalcemic potencies. Similar results were obtained, including the lesser effect of HCT, in studies on inhibition of gastric emptying involving the administration of an Evan's blue test meal. These gastric effects of calcitonin appear not to be mediated by changes in serum calcium.