Genetic Variation in Activity of Enzymes Involved in Synthesis of Catecholamines

A genetic analysis of differences in adrenal phenylethanolamine N-methyltransferase (EC 2.1.1.X) and tyrosine hydroxylase (EC 1.99.1.X.) and brain tyrosine hydroxylase was performed in three inbred mouse strains. In adrenal glands, the pattern of inheritance of both enzymes was similar; genes carrie...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1972-09, Vol.69 (9), p.2448-2450
Hauptverfasser:	Kessler, S., Ciaranello, R. D., Shire, J. G. M., Barchas, J. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Adrenal Glands - enzymology Amino Alcohols Analysis of Variance Animals Biological Sciences: Genetics Brain Brain - enzymology Carbon Isotopes Catecholamines Enzymes Genes Genes, Dominant Genetic inheritance Genetic Variation Hybridity Inbred strains Inheritance patterns Male Medical genetics Methyltransferases Mice Mice, Inbred Strains Mixed Function Oxygenases Phenethylamines S-Adenosylmethionine Tyrosine 3-Monooxygenase
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Zusammenfassung:	A genetic analysis of differences in adrenal phenylethanolamine N-methyltransferase (EC 2.1.1.X) and tyrosine hydroxylase (EC 1.99.1.X.) and brain tyrosine hydroxylase was performed in three inbred mouse strains. In adrenal glands, the pattern of inheritance of both enzymes was similar; genes carried by the CBA/J strain appeared to be dominant to those of the other strains. The pattern of inheritance of tyrosine hydroxylase activity in adrenals differed from that in the brain. In both tissues, dominant genes appeared to determine intermediate, rather than extreme, levels of enzyme activities.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.69.9.2448