Changes in Rabbit-Liver Lysosomes and Fructose 1,6-Bisphosphatase Induced by Cold and Fasting

Exposure of rabbits to cold or fasting results in marked increases in the number and size of liver lysosomes, associated with increases in the total and ``free'' proteolytic activity. Changes in lysosomal morphology also indicate increased activity and fragility. These effects of cold and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1973-12, Vol.70 (12), p.3674-3678
Hauptverfasser:	Pontremoli, S., Melloni, E., Salamino, F., Franzi, A. T., De Flora, A., Horecker, B. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences: Biochemistry Cell Fractionation Cold Temperature Electrophoresis Enzymes Fasting Female Fructose-Bisphosphatase - metabolism Fructosephosphates Gels Hepatocytes Liver Liver - cytology Liver - enzymology Low temperature Lysosomes Microscopy, Electron Peptide Hydrolases - metabolism Rabbits Vacuoles
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Beschreibung
Zusammenfassung:	Exposure of rabbits to cold or fasting results in marked increases in the number and size of liver lysosomes, associated with increases in the total and ``free'' proteolytic activity. Changes in lysosomal morphology also indicate increased activity and fragility. These effects of cold and fasting are correlated with decreases in the levels of liver fructose bisphosphatase (EC 3.1.3.11) activity and changes in the molecular properties of the purified enzyme, including the loss of a small peptide containing the only tryptophan residue in the peptide chain.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.70.12.3674