Carcinoembryonic Antigen (CEA): Activity of Meconium and Normal Colon Extracts

Precipitating rabbit antiserum reacting with the carcinoembryonic antigen (CEA) formed a band of identity with normal colon extract (NCE), tumor extract (TE) and meconium extract (ME) in Ouchterlony gel. Absorption with normal colon only reduced activity with NCE in the precipitation assay. Assays u...

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Veröffentlicht in:	Immunological communications 1973, Vol.2 (1), p.15-24
1. Verfasser:	Rule, Allyn H.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABO Blood-Group System Animals Antibody Specificity Blood Carcinoembryonic Antigen - analysis Colon - immunology Colonic Neoplasms - immunology Complement Fixation Tests Dextrans Electrophoresis, Starch Gel Female Goats - immunology Humans Immune Sera Immunodiffusion Infant, Newborn Meconium - immunology Pregnancy Rabbits - immunology Tissue Extracts
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Zusammenfassung:	Precipitating rabbit antiserum reacting with the carcinoembryonic antigen (CEA) formed a band of identity with normal colon extract (NCE), tumor extract (TE) and meconium extract (ME) in Ouchterlony gel. Absorption with normal colon only reduced activity with NCE in the precipitation assay. Assays using quantitative complement fixation at final antibody titers suggest that molecular differences exist between NCE, ME and CEA. Their molecular relationships are currently being investigated in delayed hypersensitivity systems and by physico-chemical analyses.
ISSN:	0882-0139 0090-0877 1532-4311
DOI:	10.3109/08820137309022877