Antithrombin 3. Protection against death after injection of thromboplastin

Intravenous injection of autologous lipoprotein (thromboplastin) or thrombin produced a lethal, hemorrhagic syndrome in chicken embryos. The embryos could be protected from this fatal result by injection of antithrombin III, an alpha(2)-globulin (molecular weight 60,000 to 80,000) purified from huma...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1969-10, Vol.166 (3904), p.517
Hauptverfasser:	Mann, Jr, L T, Jensenius, J C, Simonsen, M, Abildgaard, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-Globulins - pharmacology Animals Antithrombins - pharmacology Blood Protein Electrophoresis Cattle Chick Embryo Electrophoresis, Disc Guinea Pigs Hemorrhage - prevention & control Heparin - pharmacology Humans Injections, Intravenous - adverse effects Molecular Weight Thromboplastin - adverse effects
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Beschreibung
Zusammenfassung:	Intravenous injection of autologous lipoprotein (thromboplastin) or thrombin produced a lethal, hemorrhagic syndrome in chicken embryos. The embryos could be protected from this fatal result by injection of antithrombin III, an alpha(2)-globulin (molecular weight 60,000 to 80,000) purified from human, bovine, and guinea pig blood. Heparin also protected the embryos, but other inhibitors were less protective.
ISSN:	0036-8075
DOI:	10.1126/science.166.3904.517