The Metabolism of Salbutamol in Man

Abstract 1. The fate of 3H-salbutamol given orally, by aerosol and intravenously, has been investigated in asthmatic patients. 2. Salbutamol was extensively metabolized to a polar metabolite. Both free salbutamol and the metabolite were excreted in the urine, the ratio varying with the route of admi...

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Veröffentlicht in:	Xenobiotica 1973-01, Vol.3 (2), p.113-120
Hauptverfasser:	Evans, Marion E., Walker, S. R., Brittain, R. T., Paterson, J. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adrenergic beta-Agonists - administration & dosage Adrenergic beta-Agonists - metabolism Adrenergic beta-Agonists - pharmacology Adrenergic beta-Agonists - urine Aerosols Animals Asthma - metabolism Butylamines - administration & dosage Butylamines - metabolism Butylamines - pharmacology Butylamines - urine Ethanolamines - administration & dosage Ethanolamines - metabolism Ethanolamines - pharmacology Ethanolamines - urine Feces - metabolism Freeze Drying Glucuronates - metabolism Guinea Pigs Hydrolysis In Vitro Techniques Injections, Intravenous Phenethylamines - administration & dosage Phenethylamines - metabolism Phenethylamines - pharmacology Phenethylamines - urine Spectrophotometry, Ultraviolet Time Factors Trachea - drug effects Tritium
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Beschreibung
Zusammenfassung:	Abstract 1. The fate of 3H-salbutamol given orally, by aerosol and intravenously, has been investigated in asthmatic patients. 2. Salbutamol was extensively metabolized to a polar metabolite. Both free salbutamol and the metabolite were excreted in the urine, the ratio varying with the route of administration. 3. The metabolite found in man is different from that previously found in the rat and the rabbit. Details of its chemical properties are given.
ISSN:	0049-8254 1366-5928
DOI:	10.3109/00498257309151506