CLINICAL EFFICACY OF AZTREONAM FOR REFRACTORY INFECTIONS IN CHILDREN

CLINICAL EFFICACY OF AZTREONAM FOR REFRACTORY INFECTIONS IN CHILDREN

Aztreonam (AZT) is the first monobactam antibiotic that has significant activity in vitro against aerobic Gram-negative bacteria but not against Gram-positive or anaerobic bacteria. The agent was used 120-200mg/kg in daily dose to treat 10 hospitalized cases of refractory infections in pediatric fie...

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Veröffentlicht in:Japanese journal of antibiotics 1985/11/25, Vol.38(11), pp.3349-3357
Hauptverfasser: HAMADA, FUMIHIKO, OGURA, HIDEO, KITAMURA, ISAMU, MATSUMOTO, KENJI, ARAKI, KUMIKO, KURAMITSU, MAKOTO, FUJIEDA, MIKIYA, KURASHIGE, TAKANOBU, OGURA, YUKIKO
Format: Artikel
Sprache:jpn
Schlagworte:
Adolescent
Adult
Age Factors
Aztreonam - pharmacology
Aztreonam - therapeutic use
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Child
Child, Preschool
Drug Evaluation
Female
Gram-Negative Bacteria - drug effects
Humans
Infant
Male
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Zusammenfassung:Aztreonam (AZT) is the first monobactam antibiotic that has significant activity in vitro against aerobic Gram-negative bacteria but not against Gram-positive or anaerobic bacteria. The agent was used 120-200mg/kg in daily dose to treat 10 hospitalized cases of refractory infections in pediatric field. There were 3 cases of 1 pneumonia, 4 cases of urinary tract infections, 2 cases of pyogenic meningitis and 1 case of septicemia. Seven aerobic Gram-negative bacteria were isolated from patients and 4 bacteria were eradicated by treatment. Clinical cure was achieved in 8 out of 10 cases without adverse reaction or drug toxicity.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.38.3349