Ortho -Functionalization of Pillar[4]arene[1]benzoquinone Monoxime via Selective 1,4-Addition of Grignard Reagents

-functionalization of pillar[ ]arenes has been a formidable challenge, partially due to the fragility of their macrocyclic skeletons. In this concise report, we describe a facile synthetic method for monoarylation/alkylation at the position to the oxime functionality in pillar[4]arene[1]benzoquinone monoxime ( ) via addition of Grignard reagents. The described method enables the creation of various mono- -alkyl/aryl-substituted pillar[5]arene derivatives that were previously inaccessible.