A role for Ca2+ in the effect of very low frequency electromagnetic field on the blastogenesis of human lymphocytes

The DNA synthesis of lymphocytes triggered by phytohemagglutinin or phorbol‐myristate‐acetate is strongly reduced by the externally applied electromagnetic field (ELF). Ca2+ uptake by stimulated lymphocytes is also reduced by ELF. The effect appears to be synergistic with that of the well‐known calc...

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Veröffentlicht in:	FEBS letters 1985-02, Vol.181 (1), p.28-32
Hauptverfasser:	Conti, P., Gigante, G.E., Alesse, E., Cifone, M.G., Fieschi, C., Reale, M., Angeletti, P.U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Ca2+ flux Calcium - metabolism Cell physiology CRPMI, complete medium RPMI 1640 Effects of physical and chemical agents Electromagnetic field Electromagnetic Phenomena ELF, very low frequency elec-tromagnetic field Fundamental and applied biological sciences. Psychology Humans Lymphocyte Activation - drug effects Lymphocyte blastogenesis Lymphocytes - metabolism Molecular and cellular biology PHA, phytohemagglutinin Phorbol-myristate-acetate Phytohemagglutinin Phytohemagglutinins - pharmacology PMA, phorbol-myristate-acetate Tetradecanoylphorbol Acetate - pharmacology Thymidine - metabolism Verapamil Verapamil - pharmacology
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Zusammenfassung:	The DNA synthesis of lymphocytes triggered by phytohemagglutinin or phorbol‐myristate‐acetate is strongly reduced by the externally applied electromagnetic field (ELF). Ca2+ uptake by stimulated lymphocytes is also reduced by ELF. The effect appears to be synergistic with that of the well‐known calcium blocker agent, verapamil.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(85)81107-8