Stem Cell Markers LGR5, LGR4 and Their Immediate Signalling Partners are Dysregulated in Preeclampsia

Stem Cell Markers LGR5, LGR4 and Their Immediate Signalling Partners are Dysregulated in Preeclampsia

Leucine-rich repeat-containing G protein-coupled receptors 5/4 (LGR5/LGR4) are critical stem cell markers in epithelial tissues including intestine. They agonise wingless-related integration site (WNT) signalling. Until now, LGR5/LGR4 were uncharacterised in placenta, where analogous functions may e...

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Veröffentlicht in:Stem cell reviews and reports 2024-12
Hauptverfasser: Wong, Georgia P, Hartmann, Sunhild, Nonn, Olivia, Cannon, Ping, Nguyen, Tuong-Vi, Kandel, Manju, de Alwis, Natasha, Murphy, Ciara N, Pritchard, Natasha, Dechend, Ralf, Hannan, Natalie J, Tong, Stephen, Simmons, David G, Kaitu'u-Lino, Tu'uhevaha J
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Sprache:eng
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Zusammenfassung:Leucine-rich repeat-containing G protein-coupled receptors 5/4 (LGR5/LGR4) are critical stem cell markers in epithelial tissues including intestine. They agonise wingless-related integration site (WNT) signalling. Until now, LGR5/LGR4 were uncharacterised in placenta, where analogous functions may exist. We characterised LGR5/LGR4, their ligands/targets in human placenta, with further assessments on dysregulation in preeclampsia/fetal growth restriction (FGR). LGR5 mRNA was unaltered in first trimester (n = 11), preterm (n = 9) and term (n = 11) placental lysate. LGR5 was enriched in human trophoblast stem cells (hTSCs) and downregulated with differentiation to extravillous trophoblasts (p 
ISSN:2629-3277