Efficacy and Safety of Dupilumab in Children With Peanut Allergy: A Multicenter, Open-Label, Phase II Study

Efficacy and Safety of Dupilumab in Children With Peanut Allergy: A Multicenter, Open-Label, Phase II Study

Peanut allergy is a potentially life-threatening food allergy in children. This study explored whether dupilumab, a human monoclonal immunoglobulin (Ig)G4 antibody that blocks the activity of interleukin (IL)-4/IL-13, improved safety and desensitization to peanut exposure in children with peanut all...

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Veröffentlicht in:Allergy (Copenhagen) 2024-12
Hauptverfasser: Sindher, Sayantani B, Nadeau, Kari C, Chinthrajah, R Sharon, Leflein, Jeffrey G, Bégin, Philippe, Ohayon, Jason A, Ponda, Punita, Wambre, Erik, Liu, Jinzhong, Khokhar, Faisal A, Akinlade, Bolanle, Maloney, Jennifer, Orengo, Jamie M, Hamilton, Jennifer D, Kamal, Mohamed A, Hooper, Andrea T, Patel, Naimish, Patel, Kiran, Laws, Elizabeth, Mannent, Leda P, Radin, Allen R
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Sprache:eng
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Zusammenfassung:Peanut allergy is a potentially life-threatening food allergy in children. This study explored whether dupilumab, a human monoclonal immunoglobulin (Ig)G4 antibody that blocks the activity of interleukin (IL)-4/IL-13, improved safety and desensitization to peanut exposure in children with peanut allergy. A Phase II, 24-week, multicenter, single-arm, open-label, proof-of-concept study was conducted in the USA and Canada (NCT03793608). Children/adolescents with peanut allergy received subcutaneous dupilumab 300 mg (≥ 60 kg) or 200 mg (≥ 20 to
ISSN:1398-9995