Coupling Probiotics with CaO 2 Nanoparticle-Loaded CoFeCe-LDH Nanosheets to Remodel the Tumor Microenvironment for Precise Chemodynamic Therapy

Chemodynamic therapy (CDT) has become an emerging cancer treatment strategy with advantages of tumor-specificity, high selectivity, and low systemic toxicity. However, it usually suffers from low therapeutic efficacy. This is caused by low hydroxyl radical (·OH) yield arising because of the relative...

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Veröffentlicht in:Advanced healthcare materials 2024-12, p.e2403373
Hauptverfasser: Si, Ruxue, Hu, Tingting, Williams, Gareth R, Yang, Yu, Yang, Shuqing, Yan, Dan, Liang, Ruizheng, Ji, Weiping
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Sprache:eng
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Zusammenfassung:Chemodynamic therapy (CDT) has become an emerging cancer treatment strategy with advantages of tumor-specificity, high selectivity, and low systemic toxicity. However, it usually suffers from low therapeutic efficacy. This is caused by low hydroxyl radical (·OH) yield arising because of the relatively high pH, overexpressed glutathione, and low H O concentration in the tumor microenvironment (TME). Herein, a probiotic metabolism-initiated pH reduction and H O supply-enhanced CDT strategy is reported to eradicate tumors by generating ·OH, in which Lactobacillus acidophilus is coupled with CoFeCe-layered double hydroxide nanosheets loaded with CaO nanoparticles (NPs) as a chemodynamic platform for high-efficiency CDT (CaO /LDH@L. acidophilus). Owing to the hypoxia tropism of L. acidophilus, CaO /LDH@L. acidophilus exhibits increased accumulation at tumor sites compared with the CaO /LDH. The CaO NPs loaded on CoFeCe-LDH nanosheets are decomposed into H O in the TME. L. acidophilus metabolite-induced pH reduction (
ISSN:2192-2659