The Relationship between D'Amico and ISUP Risk Classifications and 68 Ga-PSMA PET/CT SUVmax Values in Newly Diagnosed Prostate Cancers

This study aimed to evaluate the relationship between pathological and clinical risk classifications in newly diagnosed prostate cancer patients, and Ga-PSMA PET/CT data and serum Prostate Specific Antigen (PSA) values. A total of 203 patients who were diagnosed with prostate cancer between 2019 and 2023, who had not yet received treatment and who underwent Ga-PSMA PET/CT for staging purposes were included in this study. There was a substantial correlation between D'Amico risk classification, Gleason score, ISUP classification, and the presence or absence of metastasis ( < 0.0001). The median SUVmax value of the prostate gland and the D'Amico risk classification were statistically significantly correlated. ( < 0.0001). There was a statistically significant correlation between the ISUP classification and the PSA value and prostate gland SUVmax value ( < 0.0001). There was a significant correlation between the median SUVmax values of the prostate gland at the time of diagnosis and the patients with and without metastases ( < 0.0001). According to the data obtained from ROC analysis, patients with prostate gland SUVmax values of 8.75 and above were found to have a high probability of metastasis with a sensitivity of 78.9% and a specificity of 59.05%. Our study showed that Ga-PSMA PET/CT is a highly effective method for staging newly diagnosed high-risk prostate cancer. The probability of metastasis was found to be dramatically increased in Gleason 8 and above. According to D'Amico risk classification, metastasis was detected in at least half of high-risk patients. Since the sensitivity of metastasis was 78.9% in patients with prostate gland SUVmax value above 8.75, we think that these patients should be carefully reported in terms of metastasis.