The Brain Renin-Angiotensin System and the Development of Doc - Salt Hypertension

The effect of captopril, given in the drinking fluid, on the development of DOC-salt hypertension was analyzed. Although captopril did not prevent an increase in blood pressure (BP) elicited by DOC-salt, captopril did diminish BP in both DOC-salt and control animals. From the first week of treatment...

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Veröffentlicht in:Clinical and experimental hypertension (1993) 1985, Vol.A7 (9), p.1259-1268
Hauptverfasser: Basso, Nidia, Ruiz, Patricia, Kurnjek, MarÍA L., Cannata, M. A., Taquini, A. C.
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Sprache:eng
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Zusammenfassung:The effect of captopril, given in the drinking fluid, on the development of DOC-salt hypertension was analyzed. Although captopril did not prevent an increase in blood pressure (BP) elicited by DOC-salt, captopril did diminish BP in both DOC-salt and control animals. From the first week of treatment DOC-salt rats increased their fluid intake (FI). At the end of the experiment, captopril reduced this increment (655% to 357%). At the same time plasma angiotensinogen was diminished (-35%; P < 0.001) and cerebrospinal fluid (CSF) substrate concentration increased (+33%; P < 0.02) in DOC-salt rats, captopril did not modify these changes. In control rats captopril did not alter FI, depleted plasma angiotensinogen, (-73%; P < 0.001), did not change the central prohormone and increased plasma renin activity (PRA) (+260%; P < 0.001). In conclusion: CSF angiotensinogen concentration changes as previously found in CNS while a clear dissociation between plasma and CSF angiotensinogen was found in DOC-salt rats. In these animals the hypertension was not clearly affected by captopril treatment. However the effect of the converting enzyme inhibitor suggests that the central renin-angiotensin system could participate in the increase in FI.
ISSN:1064-1963
0730-0077
1525-6006
DOI:10.3109/10641968509073589