The Brain Renin-Angiotensin System and the Development of Doc - Salt Hypertension
The effect of captopril, given in the drinking fluid, on the development of DOC-salt hypertension was analyzed. Although captopril did not prevent an increase in blood pressure (BP) elicited by DOC-salt, captopril did diminish BP in both DOC-salt and control animals. From the first week of treatment...
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Veröffentlicht in: | Clinical and experimental hypertension (1993) 1985, Vol.A7 (9), p.1259-1268 |
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Zusammenfassung: | The effect of captopril, given in the drinking fluid, on the development of DOC-salt hypertension was analyzed. Although captopril did not prevent an increase in blood pressure (BP) elicited by DOC-salt, captopril did diminish BP in both DOC-salt and control animals. From the first week of treatment DOC-salt rats increased their fluid intake (FI). At the end of the experiment, captopril reduced this increment (655% to 357%). At the same time plasma angiotensinogen was diminished (-35%; P < 0.001) and cerebrospinal fluid (CSF) substrate concentration increased (+33%; P < 0.02) in DOC-salt rats, captopril did not modify these changes. In control rats captopril did not alter FI, depleted plasma angiotensinogen, (-73%; P < 0.001), did not change the central prohormone and increased plasma renin activity (PRA) (+260%; P < 0.001).
In conclusion: CSF angiotensinogen concentration changes as previously found in CNS while a clear dissociation between plasma and CSF angiotensinogen was found in DOC-salt rats. In these animals the hypertension was not clearly affected by captopril treatment. However the effect of the converting enzyme inhibitor suggests that the central renin-angiotensin system could participate in the increase in FI. |
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ISSN: | 1064-1963 0730-0077 1525-6006 |
DOI: | 10.3109/10641968509073589 |